LymphedemaV1, Main, Exploration, bibRecord, 008D25

A family study of lymphedema of the leg in a lymphatic filariasis-endemic area

Identifieur interne : 008D25 ( Main/Exploration ); précédent : 008D24; suivant : 008D26

A family study of lymphedema of the leg in a lymphatic filariasis-endemic area

Auteurs : Karen T. Cuenco [États-Unis, Haïti] ; M. Elizabeth Halloran ; Jacky Louis-Charles ; Patrick J. Lammie

Source :

The American journal of tropical medicine and hygiene [ 0002-9637 ] ; 2004.

RBID : Pascal:04-0375020

Descripteurs français

KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Caractéristiques familiales, Facteurs de risque, Facteurs sexuels, Femelle, Filariose lymphatique (), Filariose lymphatique (épidémiologie), Haïti (épidémiologie), Humains, Lymphoedème (génétique), Lymphoedème (épidémiologie), Mâle, Pedigree, Répartition par âge, Sujet âgé, Sujet âgé de 80 ans ou plus.
MESH :
- génétique : Lymphoedème.
- épidémiologie : Filariose lymphatique, Haïti, Lymphoedème.
Pascal (Inist)
- Adolescent, Adulte, Adulte d'âge moyen, Caractéristiques familiales, Facteurs de risque, Facteurs sexuels, Femelle, Filariose lymphatique, Humains, Lymphoedème, Etude familiale, Filariose lymphatique, Mâle, Médecine tropicale, Homme, Haiti, Jambe, Pedigree, Répartition par âge, Sujet âgé, Sujet âgé de 80 ans ou plus.
Wicri :
- geographic : Haïti.
- topic : Homme.

English descriptors

KwdEn :
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Elephantiasis, Filarial (complications), Elephantiasis, Filarial (epidemiology), Family Characteristics, Family study, Female, Haiti, Haiti (epidemiology), Human, Humans, Leg, Lymphatic filariasis, Lymphedema, Lymphedema (epidemiology), Lymphedema (genetics), Male, Middle Aged, Pedigree, Risk Factors, Sex Factors, Tropical medicine.
MESH :
- geographic , epidemiology : Haiti.
- complications : Elephantiasis, Filarial.
- epidemiology : Elephantiasis, Filarial, Lymphedema.
- genetics : Lymphedema.
- Adolescent, Adult, Age Distribution, Aged, Aged, 80 and over, Family Characteristics, Female, Humans, Male, Middle Aged, Pedigree, Risk Factors, Sex Factors.

Abstract

The risk of filarial lymphedema may not be equivalent for all members of filaria-exposed populations, While evidence for a genetic factor that influences acquisition of infection has been growing, very little work has addressed whether there is a genetic basis to the development of disease due to lymphatic filariasis. We designed a family study of lymphedema in a rural community in Haiti to assess disease aggregation. Three hundred sixty-eight female patients sixteen years of age or older were enrolled at a lymphedema treatment clinic between June 1995 and December 1999. After applying additional eligibility criteria, 172 probands were enrolled into the family study for detailed pedigree collection between September 1998 and December 1999. Fifty-three lymphedema cases were identified among the prohands' parents, full-siblings, children, half-siblings, and mating partners of the parents. Twelve of the 53 cases were among males. The proportion of cases occurring in a biologic parent of the proband was higher than in unrelated individuals married into the proband's family (P = 0.0010). This is the first large family study based on pedigrees to assess the familial aggregation of lymphedema due to filariasis. This family study will be useful to investigate the role of genes and environment in the development of filarial-related lymphedema.

Affiliations:

Le document en format XML

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<author><name sortKey="Louis Charles, Jacky" sort="Louis Charles, Jacky" uniqKey="Louis Charles J" first="Jacky" last="Louis-Charles">Jacky Louis-Charles</name>
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<author><name sortKey="Lammie, Patrick J" sort="Lammie, Patrick J" uniqKey="Lammie P" first="Patrick J." last="Lammie">Patrick J. Lammie</name>
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<term>Age Distribution</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Elephantiasis, Filarial (complications)</term>
<term>Elephantiasis, Filarial (epidemiology)</term>
<term>Family Characteristics</term>
<term>Family study</term>
<term>Female</term>
<term>Haiti</term>
<term>Haiti (epidemiology)</term>
<term>Human</term>
<term>Humans</term>
<term>Leg</term>
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<term>Lymphedema (epidemiology)</term>
<term>Lymphedema (genetics)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Pedigree</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
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<term>Facteurs de risque</term>
<term>Facteurs sexuels</term>
<term>Femelle</term>
<term>Filariose lymphatique ()</term>
<term>Filariose lymphatique (épidémiologie)</term>
<term>Haïti (épidémiologie)</term>
<term>Humains</term>
<term>Lymphoedème (génétique)</term>
<term>Lymphoedème (épidémiologie)</term>
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<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Lymphoedème</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Filariose lymphatique</term>
<term>Haïti</term>
<term>Lymphoedème</term>
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<term>Adult</term>
<term>Age Distribution</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Family Characteristics</term>
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<term>Humans</term>
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<term>Middle Aged</term>
<term>Pedigree</term>
<term>Risk Factors</term>
<term>Sex Factors</term>
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<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Caractéristiques familiales</term>
<term>Facteurs de risque</term>
<term>Facteurs sexuels</term>
<term>Femelle</term>
<term>Filariose lymphatique</term>
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<front><div type="abstract" xml:lang="en">The risk of filarial lymphedema may not be equivalent for all members of filaria-exposed populations, While evidence for a genetic factor that influences acquisition of infection has been growing, very little work has addressed whether there is a genetic basis to the development of disease due to lymphatic filariasis. We designed a family study of lymphedema in a rural community in Haiti to assess disease aggregation. Three hundred sixty-eight female patients sixteen years of age or older were enrolled at a lymphedema treatment clinic between June 1995 and December 1999. After applying additional eligibility criteria, 172 probands were enrolled into the family study for detailed pedigree collection between September 1998 and December 1999. Fifty-three lymphedema cases were identified among the prohands' parents, full-siblings, children, half-siblings, and mating partners of the parents. Twelve of the 53 cases were among males. The proportion of cases occurring in a biologic parent of the proband was higher than in unrelated individuals married into the proband's family (P = 0.0010). This is the first large family study based on pedigrees to assess the familial aggregation of lymphedema due to filariasis. This family study will be useful to investigate the role of genes and environment in the development of filarial-related lymphedema.</div>
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Serveur d'exploration sur le lymphœdème

A family study of lymphedema of the leg in a lymphatic filariasis-endemic area

A family study of lymphedema of the leg in a lymphatic filariasis-endemic area

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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